Design of on-target FAAH inhibitors.
نویسنده
چکیده
In this issue of Chemistry & Biology, Alexander and Cravatt propose a model for the binding of carbamate inhibitors to fatty acid amide hydrolase (FAAH), the enzyme that breaks down signaling lipids. Using competitive activity-based protein profiling and click chemistry, they designed potent and selective FAAH inhibitors and characterized their off-target reactions.
منابع مشابه
Design, Synthesis, and Characterization of α-Ketoheterocycles That Additionally Target the Cytosolic Port Cys269 of Fatty Acid Amide Hydrolase
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ورودعنوان ژورنال:
- Chemistry & biology
دوره 12 11 شماره
صفحات -
تاریخ انتشار 2005